So, there was a lot of fuzz about a recent talk by 
Karsten Nohl et al. at BlackHat about the the unsecurity of current USB implementations (on the computer side) which happily load drivers for all kinds of devices as soon as a (potentially malicious) USB stick is connected.
I 
completely agree that, as shipped, most computer systems will be susceptible to this attack, and assume that all of their attacks will work as advertised. What I 
don't agree with at all is their conclusion, which boils down that no effective defenses exist.
While I haven't made my homework to develop a defense, I want to at least show the mechanism in current Linux kernels to limit binding of potentially dangerous 
drivers to specific devices, so that e.g. a inserted USB-stick would only be mounted as a block device, and its malicious keyboard interface be ignored.
Binding of Drivers
A linux-module can claim ownership of certain usb vendor/device ids or device classes. Those are visible when looking at the 
modinfo of a kernel module, to facilitate autoloading of modules, but are also registered in internal kernel structures, so that drivers compiled in statically directly can be mated with the proper devices:
$ modinfo snd-usb-audio
filename:       /lib/modules/3.15.8-1-ARCH/kernel/sound/usb/snd-usb-audio.ko.gz
license:        GPL
description:    USB Audio
author:         Takashi Iwai 
alias:          usb:v*p*d*dc*dsc*dp*ic01isc01ip*in*
alias:          usb:v0D8Cp0103d*dc*dsc*dp*ic*isc*ip*in*
alias:          usb:v*p*d*dc*dsc*dp*ic01isc03ip*in*
alias:          usb:v200Cp100Bd*dc*dsc*dp*ic*isc*ip*in*
(...)
This information currently comes from the MODULE_DEVICE_TABLE of sound/usb/card.c, stored in an array called 
usb_audio_ids. The bold one is the "default class", the others all are included in the "quirks table", which includes all exceptions from the default class.
static struct usb_device_id usb_audio_ids [] = {
#include "quirks-table.h"
     { .match_flags = (USB_DEVICE_ID_MATCH_INT_CLASS | USB_DEVICE_ID_MATCH_INT_SUBCLASS),
       .bInterfaceClass = USB_CLASS_AUDIO,
       .bInterfaceSubClass = USB_SUBCLASS_AUDIOCONTROL },
     { }                                         /* Terminating entry */
 };
MODULE_DEVICE_TABLE(usb, usb_audio_ids);
 
On connection of a USB device, the kernel will look through all its currently registered modules that claim to support USB devices (by registering those tables with the kernel) and bind devices to drivers (and if it doesn't succeed, it will call udev/hotplug to load a module that does). 
The Vulnerability
So, if you connect a particular USB headset, the electronics of which I have laying around... you get a new sound device in ALSA...
[root@optiplex devices]# aplay -l
 
**** List of PLAYBACK Hardware Devices ****
(...)
card 1: Headset [Logitech USB Headset], device 0: USB Audio [USB Audio]
  Subdevices: 1/1
  Subdevice #0: subdevice #0
 
But also a new keyboard! (the mute/volume buttons on the headset, but those could be arbitrary buttons entering text, too).
[root@optiplex devices]# xinput
⎡ Virtual core pointer                     id=2 [master pointer  (3)]
⎜   ↳ Virtual core XTEST pointer               id=4 [slave  pointer  (2)]
⎜   ↳ Logitech USB-PS/2 Optical Mouse          id=8 [slave  pointer  (2)]
⎣ Virtual core keyboard                    id=3 [master keyboard (2)]
    ↳ Virtual core XTEST keyboard              id=5 [slave  keyboard (3)]
    ↳ Power Button                             id=6 [slave  keyboard (3)]
    ↳ Power Button                             id=7 [slave  keyboard (3)]
    ↳ Das Keyboard                             id=9 [slave  keyboard (3)]
    ↳ Logitech Logitech USB Headset            id=10 [slave  keyboard (3)]
 
 
If you look in the sysfs filesystem, you can see, that the USB headset (usb device 
5-1) has 4 distinct functions (
.0 -- 
.3) on configuration 
:1.
[root@optiplex /sys/bus/usb/devices/5-1]# ls
5-1:1.0       bcdDevice     maxchild
5-1:1.1       bmAttributes   port
5-1:1.2       busnum     power
5-1:1.3       configuration  product
authorized      descriptors    quirks
avoid_reset_quirk    dev     removable
bConfigurationValue  devnum     remove
bDeviceClass      devpath     speed
bDeviceProtocol      driver     subsystem
bDeviceSubClass      ep_00     uevent
bMaxPacketSize0      idProduct     urbnum
bMaxPower      idVendor     version
bNumConfigurations   ltm_capable
bNumInterfaces      manufacturer
And those are described by the (very lengthy) lsusb -v output, which I'll not reproduce completely here, just try it for yourself on any USB device.
Bus 005 Device 006: ID 046d:0a0b Logitech, Inc. ClearChat Pro USB
Device Descriptor:
 (...)
  bNumConfigurations      1
  Configuration Descriptor: (configuration #1 starts here)
    bLength                 9
(...)
    Interface Descriptor: (interface 1:0)
(...)
       bDescriptorType         4
       bInterfaceNumber        0
 
(...)
    bInterfaceClass         1 Audio
      bInterfaceSubClass      1 Control Device
 
(...)
      AudioControl Interface Descriptor: (detailed info about audio capabilities)
        bLength                10
(...)
    Interface Descriptor: (interface 1:3)
      bInterfaceNumber        3
(...)
      bInterfaceClass         3 Human Interface Device
      bInterfaceSubClass      0 No Subclass
      bInterfaceProtocol      0 None
      iInterface              0 
 
So, here you have it, one device that (legitimately) is both a soundcard and a keyboard/mouse (e.g. an human interface device). Given enough motiuvation, code could be written for the controller inside the soundcard that enters arbitary text to my computer. And that's basically the vulnerability presented in the Black Hat Presentation by Nohl et al.
Defense
But, you can easily turn off this automatic binding, at least on Linux, with one single command:
[root@optiplex ~]# echo 0 >/sys/bus/usb/drivers_autoprobe 
 
Now, whenever you connect a USB device to your computer, it will not automatically connect the usb-soundcard to the ALSA subsystem and the volume buttons to the hidraw/keyboard driver. If I now connect the aforementioned soundcard, I'll not get a new keyboard in xinput, nor a soundcard in ALSA (and also not a network- or block-device for a network card or USB disk).
The only thing I'll get in my dmesg is the message, that an USB device has been connected:
[13399.092113] usb 5-1: USB disconnect, device number 6
[13405.245389] usb 5-1: new full-speed USB device number 7 using uhci_hcd
And to manually bind this device, you first have to choose the appropriate USB configuration...
# echo 1 >/sys/bus/usb/devices/5-1/bConfigurationValue 
 
...and tell the usb audio driver to bind to that device.
# echo 5-1:1.0 >/sys/bus/usb/drivers/snd-usb-audio/bind
 
Now you have the USB audio interface, but not the keyboard, yet... If you wanted, you'd just bind usb-hid to interface 3.
# echo 5-1:1.3 >/sys/bus/usb/drivers/usbhid/bind 
To verify that your keyboard presses aren't registed from the connected device before, and are registered after binding, you can run "xev" and press the volume buttons (note: those, in principle, could enter arbitrary text to your computer, depending on the programming of the controller in the device).
KeyRelease event, serial 38, synthetic NO, window 0x3800001,
    root 0x1dc, subw 0x3800002, time 13880057, (41,58), root:(2384,618),
    state 0x10, keycode 123 (keysym 0x1008ff13, XF86AudioRaiseVolume), same_screen YES,
    XLookupString gives 0 bytes:
    XFilterEvent returns: False
The most often quoted use-case if obviously connection of a usb-storage device, e.g. an external harddrive or flash-stick.
[14567.888596] usb 6-1: new high-speed USB device number 4 using ehci-pci
# echo 1 >/sys/bus/usb/devices/6-1/bConfigurationValue
# echo 6-1:1.0 >/sys/bus/usb/drivers/usb-storage/bind
[14667.692717] usb-storage 6-1:1.0: USB Mass Storage device detected
[14667.692936] scsi7 : usb-storage 6-1:1.0
[14668.696482] scsi 7:0:0:0: Direct-Access     TOSHIBA  MK4309MAT        G5.0 PQ: 0 ANSI: 0 CCS
[14668.698461] sd 7:0:0:0: [sdd] 8452080 512-byte logical blocks: (4.32 GB/4.02 GiB)
 
(yes, it's a very, very crappy and old USB harddisk)
Proper user-interface, current lack thereof.
To convert all this sysfs poking into a proper user-friendly software, one will have to...
- On computer startup, disable  autoprobe (probably there's a kernel command line for that).
- Statically configure the minimal interfaces used (e.g. the main usb keyboard, trackpad/mouse, ...).
- During normal operation, watch hotplug-events or poll the sysfs filesystem for newly inserted usb devices.
- Verify presented configurations of USB devices and their interfaces with a policy (e.g. enable only usb-storage devices, e.g. "thumbdrivers"
- Ask the user, if he's happy with this device.
- On successful verification, only bind the single necessary driver (e.g. usb-storage) to the proper interface of the device.
Of course, for certain devices more sophisticated verification schemes could be envisioned, checking certificates, downloading firmware for verification (which, again, might be forged, ...).
 
The "Authorized" Mechanism
There's a second mechanism to disable/enable communication with USB device using the "authorized" property of USB controllers. It's described in the 
kernel documentation.
Windows...
There seems to be a 
group policy for that... 
Local Computer Policy, Computer Configuration,Administrative Templates, System, Device Installation, and Device Installation Restrictions